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2:2 and 3:1 Meiotic disjunctions in a carrier of a reciprocal 10/14 translocation
Author(s) -
Scheres J. M. J. C.,
Hustinx Th. W. J.,
Haar B. G. A. ter,
Rutten F. J.,
MeeWienen H. H. A. M van der
Publication year - 1978
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1978.tb01202.x
Subject(s) - chromosomal translocation , meiosis , offspring , karyotype , genetics , biology , chromosome , trisomy , abortion , reciprocal , chromosomal rearrangement , pregnancy , gene , philosophy , linguistics
The offspring of a female with a reciprocal whole‐arm translocation between a chromosome No. 10 and a chromosome No. 14 is described. She gave birth to three cytogenetically different children: one with a normal, one with an abnormal but balanced, and one with an unbalanced karyotype. In these three cases, 2:2 disjunctions must have occurred during maternal meiosis. She also had a trisomy 14 abortion, which is assumed to have been caused by a 3:1 meiotic disjunction.