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Somatic segregation and Fanconi anemia
Author(s) -
Berger R.,
Bussel A.,
Schenhietzler C.
Publication year - 1977
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1977.tb01336.x
Subject(s) - fanconi anemia , somatic cell , biology , genetics , chromosome , bone marrow , acute leukemia , cancer research , leukemia , immunology , dna , gene , dna repair
A case of Fanconi anemia with terminal acute leukemia is reported. Clones with chromosome abnormalities were observed in bone marrow cells. The patterns of marker chromosome distribution in these clones suggests the occurrence of a somatic segregation mechanism.