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Cytogenetic study of 10 cases of infectious mononucleosis
Author(s) -
Watt Jessie L.,
Page B. M.,
Davidson R. J. L.
Publication year - 1977
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1977.tb00940.x
Subject(s) - mononucleosis , phytohaemagglutinin , biology , immunology , virology , chromosome , chromatid , genetics , lymphocyte , virus , gene
Cytogenetic analysis of 10 cases of infectious mononucleosis has revealed increased damage in the form of chromosome breakage and aberrations typical of viral infection, but in addition a few cells were consistently found to harbour a deleted number 22, similar to the Philadelphia chromosome. The presence of a plasma inhibitor of lymphocyte response to the mitogen phytohaemagglutinin is suggested. This inhibitor appears to have a reversible action on the patient's own lymphocytes but no inhibitory effect on control lymphocytes.