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Down syndrome and maternal age in Japan, 1950–1973
Author(s) -
Kuroki Yoshikazu,
Yamamoto Yoshifumi,
Matsui Ichiro,
Kurita Takehiko
Publication year - 1977
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1977.tb00899.x
Subject(s) - down syndrome , falling (accident) , incidence (geometry) , medicine , advanced maternal age , age groups , pediatrics , demography , pregnancy , fetus , biology , environmental health , physics , psychiatry , sociology , optics , genetics
The mean maternal age and the percentage age distribution of 2,650 mothers of children with Down syndrome were calculated for 1950–1973, from hospital records. Mean maternal age has dropped both for controls (28.55→27.37) and Down syndrome (31.26→29.59). The observed maternal age distributions were very similar to those expected in corresponding periods, from the age specific incidences of Collmann & Stoller (1962). It is conceivable that the fall in maternal age in Down syndrome in recent years has resulted from the general trend to decreasing maternal age. There has been no change in the age‐specific incidences of Down syndrome. The incidence of Down syndrome seems to be falling in Japan.