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White cell function in Down's syndrome
Author(s) -
Costello Christine,
Webber Anne
Publication year - 1976
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1976.tb01619.x
Subject(s) - phagocytosis , nitroblue tetrazolium , candida albicans , alkaline phosphatase , in vitro , abnormality , medicine , immunology , endocrinology , biology , andrology , chemistry , microbiology and biotechnology , enzyme , biochemistry , psychiatry
Neutrophil function was studied in 25 patients with Down's syndrome at a mental subnor‐mality hospital and compared with 26 normal controls. In vitro killing of Candida albicans was significantly lower in the Down's group, but there was no difference in the percentage of cells actively involved in phagocytosis or in the phagocytic index. The spontaneous nitroblue tetrazolium reduction was increased in 10 patients, but no abnormality of pero‐xidase activity or leucocyte alkaline phosphatase activity was found.