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Estimates of the heritability of serum lipoprotein and lipid concentrations
Author(s) -
Weinberg Roger,
Avet Linda M.,
Gardner Martin J.
Publication year - 1976
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1976.tb01617.x
Subject(s) - heritability , heredity , intraclass correlation , twin study , lipoprotein , medicine , endocrinology , genetics , biology , chemistry , cholesterol , chromatography , reproducibility
Heritability (h 2 ) of a serum lipid or a serum lipoprotein concentration is the proportion of variability in that concentration, among individuals, which is associated with heredity. We derive a familiar formula for estimating heritability (h 2 ) from a simple linear model for inheritance. The formula was implied by Fisher (1918) and by Wright (1921); it was derived from a consideration of variances by Jensen (1967), and from a consideration of path coefficients by Rao et al. (1974). The estimate of heritability (? 2 ) is ? 2 = 2( r MZ ‐ r DZ) for twin studies, where r mz and r DZ are the sample intraclass correlation coefficients among monozygous and dizygous twins, respectively. We calculate ? 2 for some published twin data (Heiberg 1974) on serum lipoprotein and serum lipid concentrations.