Premium
Chromosomal breaks in T and B lymphocytes in Fanconi's anemia
Author(s) -
BushkeLL Lawrence L.,
Kersey John H.,
Cervenka Jaroslav
Publication year - 1976
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1976.tb01616.x
Subject(s) - fanconi anemia , biology , malignancy , chronic lymphocytic leukemia , leukemia , chromosome , anemia , chromosome instability , genetics , immunology , microbiology and biotechnology , cancer research , medicine , dna , dna repair , gene
Three patients with Fanconi's anemia were analyzed for chromosome breaks. T and B cells were separated and grown in tissue culture with PHA and pokeweed antigen to ascertain the rates of breakage in these lymphocytic subpopulations. It has been found that there is no statistically significant difference in breakage rates in T and B lymphocytes. It is postulated that both T and B cells could be involved in the development of leukemia in Fanconi's anemia patients, assuming that chromosome breaks constitute a factor predisposing to the development of malignancy.