Premium
Familial carcinoma of the pancreas *
Author(s) -
Friedman J. M.,
Fialkow Philip J.
Publication year - 1976
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1976.tb01598.x
Subject(s) - pancreas , genetic predisposition , adenocarcinoma , pancreatitis , inheritance (genetic algorithm) , family history , carcinoma , carcinogen , pancreatic carcinoma , medicine , pathology , biology , oncology , pancreatic cancer , cancer , disease , genetics , gene
A sibship is reported in which four brothers died of adenocarcinoma of the pancreas in the seventh or eighth decade of life. None of the patients had a history of pancreatitis, other malignant neoplasms, or exposure to a known pancreatic carcinogen. This family seems to exhibit a genetic predisposition to pancreatic carcinoma late in life, but the mode of inheritance and the relative importance of genetic and environmental factors in the development of these tumors are unclear.