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Autosomal recessive muscular dystrophy in Manitoba Hutterites *
Author(s) -
Shokeir M. H. K.,
Kobrinsky N. L.
Publication year - 1976
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1976.tb01568.x
Subject(s) - muscular dystrophy , autosomal recessive inheritance , inbreeding , genetics , population , biology , disease , medicine , pathology , gene , environmental health
A slowly progressive type of muscular dystrophy affecting 11 known members of several Southern Manitoba Hutterite colonies is described. Though encompassing the facial characteristics of the facio‐scapulo‐humeral type and the proximal distribution of the limb‐girdle type, it was felt that this disease represents a distinct type of muscular dystrophy with autosomal recessive inheritance. Since all “affected” colonies can be traced to one founding colony in South Dakota, the disease may have been introduced from Europe between 1874 and 1879. Furthermore, normal fertility and a high degree of inbreeding in a genetically isolated population have contributed to the maintenance of the disease in the population.