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Genetic lipoprotein variation and lipid levels in man
Author(s) -
Berg Kåre,
Hames Curtis,
Dahlen Gosta,
Frick M. Heikki,
Krishan Iqbal
Publication year - 1976
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1976.tb00020.x
Subject(s) - genetic variation , variation (astronomy) , genetics , lipoprotein , biology , endocrinology , cholesterol , gene , physics , astrophysics
Analyses of 12 population samples have revealed that the total serum cholesterol level is significantly higher in Lp(a+) than in Lp(a–) individuals. The difference is more pronounced in middle‐aged and older people than in young persons, and the difference between Lp(a‐h) and Lp(a–) individuals is larger when LDL cholesterol rather than total serum cholesterol is considered. Lp(a –) individuals have a significantly higher triglyceride level than Lp(a +) individuals. The Lp(a) variation is genetically controlled. Thus, the present study has revealed a small but significant effect of a single, autosomal locus on lipids implicated in atherosclerosis. An association between the phenotype Lp(a +) and coronary heart disease has been demonstrated previously.