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Frequency of the carrier state for X‐linked chronic granulomatous disease among females with lupus erythematosus
Author(s) -
Humbert James R.,
Fishman Charles B.,
Weston William L.,
DeArmey Patricia A.,
Thoren Christine H.
Publication year - 1976
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1976.tb00003.x
Subject(s) - chronic granulomatous disease , medicine , immunology , lupus erythematosus , systemic lupus erythematosus , disease , pathology , antibody
Carriers for chronic granulomatous disease (CGD) and patients with lupus erythematosus (LE) share several characteristics: They are mostly females, they reduce nitroblue tetra‐zolium (NBT) poorly in their neutrophils, and, in some cases, they have similar skin lesions. We thus investigated 19 female LE patients for the presence of laboratory findings characteristic of the carrier state for CGD. None of these patients turned out to have the combined abnormality of neutrophil bactericidal activity and neutrophil NBT‐reduction that is diagnostic of CGD carrier state in the X‐linked form. An increased frequency of CGD carriers among female LE patients thus appears to be unlikely. Why some CGD carriers develop skin lesions typical of LE remains unexplained.