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The effect of structural aberrations of the chromosomes on reproductive fitness in man
Author(s) -
Morton Newton E.,
Jacobs Patricia A.,
Frackiewicz Anna,
Law Pamela,
Hilditch C. Judith
Publication year - 1975
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1975.tb01489.x
Subject(s) - pedigree chart , fertility , biology , genetics , population , evolutionary biology , demography , gene , sociology
Methods are presented to estimate relative fitness of carriers as a function of fertility, survival, and generation time in pedigrees under incomplete ascertainment. A large sample of diverse chromosomal aberrations reveals significant effects on all three parameters, giving a relative fitness of .769 ± .039. There is no significant shift in segregation frequency. Implications of these results for population dynamics of structural rearrangements are discussed. The following paper applies these methods to specific classes of aberrations.