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Genetics of the GPT system. Family, mother/child and association studies
Author(s) -
Olaisen Blørner
Publication year - 1975
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1975.tb00326.x
Subject(s) - genetics , association (psychology) , family studies , biology , medicine , psychology , psychotherapist
GPT types are presented for 150 Norwegian matings, with 454 children, and 1703 Norwegian mother/child combinations. There were five exceptions to a simple codominant inheritance pattern, all believed to be due to a segregating G pl 0 ‐allele. Rare phenotypes were encountered in two of the families and in 11 of the motherlchild combinations. Compiled family material and mother/child material are presented. No indication of association was found between GPT types and phenotypes within the ABO, Rh, MN, Hp, Gc, C3, PGM 1 , and ACP 1 systems. There is a marked association between EBS‐Ogna (epidermolysis bullosa simplex, type Ogna) affection and GPT phenotypes. This reflects the Gpt‐EBS 1 linkage phase. No evidence was found of association between GPT phenotypes and either nephrological diseases or PKU (phenylketonuria).