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Trisomy 8 in bone marrow cells of patients with polycythemia vera and myelogenous leukemia
Author(s) -
Hsu Lillian Y. F.,
Alter Andrea V.,
Hirschhorn Kurt
Publication year - 1974
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1974.tb02087.x
Subject(s) - trisomy , polycythemia vera , chronic myelogenous leukemia , bone marrow , leukemia , trisomy 8 , medicine , pathology , cytogenetics , aneuploidy , chromosome , immunology , biology , gastroenterology , cancer research , genetics , gene
In studying the bone marrow chromosomes of patients with polycythemia vera (PCV) and chronic myelogenous leukemia (CML), we have recently identified, by the current banding techniques, two cases of acquired trisomy 8. One was a patient with typical PCV and the other had a diagnosis of atypical CML. An extra No. 8 chromosome was found in approximately 60% of the marrow cells of the patient with PCV and 75% of the marrow cells of the patient with CML. Lymphocyte cultures from both patients revealed a normal chromosomal constitution. To our knowledge, thus far, there have been at least 9 cases of acquired trisomy 8 identified in patients with either PCV or CML and a total of 6 cases of acquired trisomy 9 in various hematological disorders. It is possible that acquired trisomy 8 and 9 are the most commonly involved aneuploidies in various hematological disorders especially CML and PCV. The relationship of acquired trisomy 8 or 9 to blastic crisis is to be determined.