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Prenatal chromosome determination. A study of 219 cases
Author(s) -
Wahlström J.,
Bartsch F. K.,
Lundberg J.
Publication year - 1974
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1974.tb00648.x
Subject(s) - amniocentesis , trisomy , prenatal diagnosis , chromosome , chromosome analysis , obstetrics , abortion , aneuploidy , karyotype , pregnancy , chromosome abnormality , medicine , genetics , biology , fetus , gene
The results of amniocenteses performed in connection with prenatal chromosome determinations in 219 pregnant women are reported with regard to the risks involved in sample‐taking. Two hundred and twelve of the 219 pregnant women were given correct information as to the expected child's chromosome constitution by means of the prenatal analysis. In five cases the chromosome determination was unsuccessful and no new amniocentesis was carried out. In two cases where the amniocentesis was unsuccessful the women did not return for a new attempt to take a sample. Three deviating karyotypes are reported among the 212 successful chromosome determinations: one case of trisomy‐21, one of trisomy‐18 and one case of partial trisomy for chromosome no. 14. Prenatal chromosome determination is a safe and reliable method of investigation which permits the diagnosis of chromosomal deviations of the expected child early enough during the pregnancy to permit a legal abortion to be carried out if desired.