Premium
A linkage study of phenylketonuria
Author(s) -
Berg Kare,
Saugstad Letten Fegersten
Publication year - 1974
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1974.tb00644.x
Subject(s) - recombination fraction , lod score , linkage (software) , abo blood group system , genetic linkage , genetics , phenylketonurias , medicine , biology , phenylalanine , gene mapping , gene , chromosome , amino acid
A search for linkage between phenylketonuria (PKU) and each of the following marker systems has been conducted: ABO, MN, Rh, Kell, Hp, Gc, PGM 1 . Previous suggestions of linkage between PKU and ABO could not be confirmed. For the PKU‐PGM 1 relationship, lod score values higher than I were found for recombination fractions 0.05 and 0.10, suggesting the possibility of linkage between the two loci. However, more data are needed to settle this question. Low positive lod scores for higher values of the recombination fraction were found for the PKU‐Rh and the PKU‐Hp relationships. Low positive lod score values were also found for the PKU‐Kell relationship.