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Studies in Down's syndrome
Author(s) -
Rittner Ch.,
Schwinger E.
Publication year - 1973
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1973.tb01166.x
Subject(s) - mentally retarded , abo blood group system , down syndrome , trisomy , medicine , phenotype , endocrinology , gastroenterology , genetics , psychology , biology , psychiatry , developmental psychology , gene
Two series of 88 and 53 patients with Down's syndrome and 91 other mentally retarded patients were investigated for various blood, serum and enzyme groups. No association of trisomy 21 and the following systems and factors was found: ABO, Rh(D), MNSs, K, P, Fy(a, b), Jk(a, b), Gm, (1,2), InV(1), Ag (x), Lp(a), Tf, C3, acP, PGM 1 and GPT. None of these markers was associated with age or the presence or absence of the Au/SH antigen in Down's syndrome or other mentally handicapped patients. Gm(+1) individuals were more frequent among Down and other mentally retarded patients than in normal controls. A decrease of Hp 2 individuals with age was found in the first, but not in the second group of Down patients. A possible association of Au/SH positive and tic 1‐1 individuals was found in the first. but not confirmed in the second series of patients with Down's syndrome. The control group of other mentally retarded patients exhibited a helerogeneity according to sex and age in the distribution of Gc phenotypes.