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Ring chromosome 13 and haptoglobin heterozygosity
Author(s) -
Fitzgerald P. H.
Publication year - 1973
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1973.tb01117.x
Subject(s) - locus (genetics) , haptoglobin , genetics , biology , loss of heterozygosity , chromosome , chromosome 16 , microbiology and biotechnology , ring chromosome , karyotype , allele , gene , endocrinology
Two patients with congenital ring 13 chromosome abnormality as identified by tritiated thymidine autoradiography and Giemsa banding were heterozygous for the haptoglobin locus. The ring chromosome of one patient was appreciably smaller than those from which Hp deletion was claimed. Evidence for and against the presence of the haptoglobin locus on chromosome 13 and evidence favouring chromosome 16 as the site of this locus are reviewed.