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Familial occurrence of mild hyperlipoproteinaemias
Author(s) -
Miettinen T. A.,
Penttilä I. M.,
Lampainen E.
Publication year - 1972
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1972.tb04276.x
Subject(s) - abnormality , medicine , first degree relatives , pediatrics , endocrinology , family history , psychiatry
Familial occurrence of mild hyperlipidaemias was investigated in 183 first degree relatives of 49 index patients with hypercholesterolaemia (type II A; 16 families), mixed hyperlipidaemia (MH; 23 families) and hyperglyceridaemia (type IV; 10 families). The prevalence of different hyperlipidaemias was lowest in the family members of the type II A subjects (about one third were affected) and highest in those of the type IV cases (about a half were affected). A half of the siblings had hyperlipidaemia, type IV being the predominant abnormality in the siblings of types II A and IV index patients, and MH in the siblings of the MH index patients. Of the children of the propositi about one fifth were hyperlipidaemic; the occurrence of type II A and especially of MH was low (less than 10 %) while that of the type IV abnormality was quite high (range from 10 to 27 % in different families) even in subjects under 20 years of age, particularly among children of the type IV index patients. Symptoms of arteriosclerotic manifestations appeared more frequently in hyper‐ than normolipidaemic family members. The subjects with the type II A and MH abnormality were shorter than their hyperglyceridaemic or normolipidaemic relatives.