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Haptoglobin distributions in Down's syndrome
Author(s) -
Ball J. R. B.,
Brackenridge C. J.,
McKay H.,
Pitt D. B.
Publication year - 1972
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1972.tb01465.x
Subject(s) - haptoglobin , mongoloid , phenotype , analysis of variance , down syndrome , medicine , demography , biology , genetics , population , environmental health , sociology , gene
The distributions of plasma haptoglobin (Hp) phenotypes were determined in Down's syndrome and in a control group of persons with mental retardation due to causes other than Down's syndrome. There was a trend towards a lower proportion of Mongoloid hetcrozygotes than in the control group and this became significant when the data of series from England, Hawaii, Illinois and Victoria were pooled. When Mongoloids and control subjects from Victoria were individually matched for sex, age and country of birth, there was no appreciable difference in Hp types between the groups. Examination by analysis of variance showed that mean parental ages at birth of Mongoloid patients did not vary with haptoglobin phenotype, but a positive linear regression of the proportion of heterozygous males on maternal age was observed.