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Studies on inherited antigenic variation of human serum β‐lipoprotein by passive hemagglutination
Author(s) -
Boman H.,
Lanzkowsky P.,
Berg K.
Publication year - 1972
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1972.tb01459.x
Subject(s) - antibody , antigen , isoantibodies , hemagglutination , immunology , lipoprotein , medicine , hemagglutination assay , virology , lipoprotein(a) , cholesterol , titer
Sera from 39 unselected children with thalassaemia who had received multiple blood transfusions were examined for the presence of isoantibodies to β‐lipoprotein antigens. Precipitating antibodies were found in 8 sera. In 5 of these, additional non‐precipitating antibodies were detected by the passive hemagglutination method. In another 7 serum samples, only non‐precipitating antibodies were present. Thus, 15 out of 39 sera (38.5 %) contained isoantibodies to β‐lipoprotein antigens. This frequency of antibodies to β‐lipoprotein antigens in patients with thalassaemia is the highest ever reported for any group of multiply‐transfused patients. A total of 30 antibodies were found in these 15 sera.