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Hereditary enamel hypoplasia
Author(s) -
Shokeir M. H. K.
Publication year - 1971
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1971.tb00301.x
Subject(s) - enamel hypoplasia , hypoplasia , enamel paint , inheritance (genetic algorithm) , genetics , x chromosome , biology , medicine , anatomy , dentistry , gene
An extensive family with a total of forty–one individuals who are either affected or reputed to be affected with hereditary hypoplasia of the enamel is presented. The distribution of patients, which spans four generations in this pedigree, appears to be consistent with X–linked dominant inheritance of the disorder. Considerable variability in the severity of affection was observed among both male and female patients. Whereas in the case of the latter, random X–chromosome inactivation may provide an explanation, in the case of the former another mechanism may have to be sought.