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Sex determination and gonadal differentiation in man
Author(s) -
Boczkowski Krzysztof
Publication year - 1971
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1971.tb00300.x
Subject(s) - sexual differentiation , biology , gene , genetics , gonadal ridge , chromosome , repressor , x chromosome , testis determining factor , y chromosome , gene expression , embryonic stem cell
Sex determination in man and other mammals can be accounted for in terms of three postulates. First, that unless specifically inhibited, the differentiation of the primary gonads goes in the male direction. Second, that the specific inhibiting factor is produced by a structural gene probably located on the X chromosome; this gene need be expressed only in cells of the urogenital ridge. Third, this gene is “switched off” (rendered inactive) by a repressor substance produced by a structural gene located on the Y chromosome.