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Investigations on the nature of ceruloplasmin deficiency in the newborn
Author(s) -
Shokeir M. H. K.
Publication year - 1971
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1971.tb00281.x
Subject(s) - ceruloplasmin , copper , medicine , endocrinology , enzyme , oxidase test , copper deficiency , chemistry , biochemistry , organic chemistry
Enzymatic and immunoassaies of serum ceruloplasmin were undertaken on serum samples from 100 newborn infants, their mothers, and 100 unrelated women who served as controls. The results indicate that the remarkably low levels of ceruloplasmin oxidase activity observed in the serum of neonates are not due to deficient ceruloplasmin protein synthesis but to defective copper incorporation in the synthesized protein, resulting in excess apoceruloplasmin concentration. Furthermore, serum copper studies involving both total and free copper corroborated this conclusion.