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Similarity in amino acid composition between human serum lipoproteins and histocompatibility antigens on cell membranes
Author(s) -
Berg Kåre
Publication year - 1971
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1971.tb00277.x
Subject(s) - antigen , lipoprotein , histocompatibility , amino acid , major histocompatibility complex , biology , biochemistry , chemistry , immunology , microbiology and biotechnology , cholesterol , human leukocyte antigen
Compositional relatedness appears to exist between human histocompatibility antigens and the protein part of Lp(a) lipoprotein and low density lipoprotein of human serum. Evidence for this emerged in a comparative analysis of amino acid composition by the statistical method of Metzger et al. The difference indices obtained were considerably lower than those reported previously from comparisons of apparently unrelated proteins and also lower than those from control analyses conducted in the present study. The Lp(a) lipoprotein appeared to be closely related also to murine H‐2 antigen. The results support the concept of a relationship between human serum lipoproteins and histocompatibility antigens on cell membranes.