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Evaluation of dermal patterns in Down's syndrome by predictive discrimination
Author(s) -
Bolling David R.,
Borgaonkar Digamber S.,
Herr Helen M.,
Davis Miles
Publication year - 1971
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1971.tb00273.x
Subject(s) - independence (probability theory) , medicine , correlation , audiology , statistics , mathematics , geometry
Independence of left and right dermal pattern areas were examined in Down's syndrome patients and controls. A composite score was then developed as a laboratory test to confirm the clinical diagnosis of Down's syndrome. The score demonstrates better discrimination by correctly scoring 97.7% of the individuals tested whereas the single pattern scoring method correctly scored 96.6%. An element of simplicity is also gained by using composite scores. It corrects in part the error due to correlation of the occurrence of patterns on the two sides.