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Amino acid composition of serum high density lipoprotein in patients with familial lecithin:cholesterol acyltransferase deficiency
Author(s) -
Torsvik Harald,
Boman Helge
Publication year - 1971
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1971.tb00261.x
Subject(s) - isoleucine , lecithin , methionine , threonine , phenylalanine , amino acid , serine , chemistry , arginine , valine , cysteine , high density lipoprotein , lecithin—cholesterol acyltransferase , biochemistry , endocrinology , composition (language) , medicine , leucine , cholesterol , lipoprotein , biology , enzyme , linguistics , philosophy
The amino acid composition of serum high density lipoprotein (HDL) from two patients with LCAT deficiency has been investigated. HDL from the patients was composed of two fractions, one of high molecular weight (peak 1) and one of relatively low molecular weight (peak II). The amino acid composition of peak I was close lo that of normal HDL except for lower levels of serine and glutamic acid and a higher level of isoleucine. In peak II increased amounts of histicline and arginine and decreased amounts of threonine, serine, proline, methionine, isoleucine, tyrosine, phenylalanine, and cysteine were found.