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Interaction between antilymphocyte globulin and phytohemagglutinin in human lymphocyte cultures
Author(s) -
Skoog T. Valdemar,
LindahlKiessling Kerstin
Publication year - 1970
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1970.tb01631.x
Subject(s) - lymphocyte , globulin , immunology , stimulation , biology , gamma globulin , receptor , antibody , chemistry , endocrinology , biochemistry
The interaction between antilymphocyte globulin (ALG) and phytohemagglutinin (PHA) in human lymphocyte culture has been studied. Treatment of the cells with rabbit anti‐human lymphocyte globulin (RAHLG) was found to inhibit their response to PHA. This combined ALG‐PHA effect in the initial stages of lymphocyte stimulation may be explained by a model of drug‐receptor interaction which shows that PHA is inhibited competitively by RAHLG.