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Some fine structural and functional features of lymphocytes in “acquired” agammaglobulinernia A genetically determined disease
Author(s) -
Douglas Steven D.,
Kamin Roberta M.,
Fudenberg H. Hugh
Publication year - 1970
Publication title -
clinical genetics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.543
H-Index - 102
eISSN - 1399-0004
pISSN - 0009-9163
DOI - 10.1111/j.1399-0004.1970.tb01628.x
Subject(s) - pokeweed mitogen , lymphocyte , biology , immunology , disease , serology , in vitro , genetics , pathology , medicine , concanavalin a , antibody
Present evidence for the genetic basis of “acquired” agarnmaglobulinernia has been reviewed. The previously demonstrated serologic abnormalities and the quantitative abnormalities of in vitro lymphocyte response to phytornitogens in parents of these patients are reported. In addition, a qualitative difference in the resultant cell types following in vitro stimulation of lymphocytes with pokeweed mitogen (PWM) between agammaglobulinemic patients, their parents, and normal individuals has been shown. These studies suggest that “acquired” agammaglobulinernia is an autosomal recessive disease, perhaps related to either a defective lymphocyte subpopulation or failure of cytodifferentiation.