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Atopic dermatitis: a candidate for disease‐modifying strategy
Author(s) -
Bieber T.,
Cork M.,
Reitamo S.
Publication year - 2012
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2012.02845.x
Subject(s) - atopic dermatitis , natural history , disease , medicine , asthma , biomarker , immunology , biology , pathology , genetics
The concept of disease modification has been introduced to define the therapeutic strategies aimed to break, stop, or reverse the natural course of a chronic invalidating disease. This strategy is tightly related to the biomarker‐based stratification of affected patients using genetic and other biological markers. With regard to the progress in understanding the genetic background of atopic dermatitis ( AD ), its natural history and its pivotal role in the emergence of allergic asthma, the time is mature to foster the research field of biomarkers in AD and to consider the elaboration of disease‐modifying strategies in the management of AD with the goal to stop or even reverse the atopic march.