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The indoleamine 2,3‐dioxygenase ( IDO ) pathway controls allergy
Author(s) -
Bubnoff D.,
Bieber T.
Publication year - 2012
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2012.02830.x
Subject(s) - indoleamine 2,3 dioxygenase , immunology , allergic inflammation , allergy , inflammation , atopy , medicine , immune tolerance , catabolism , immune system , tryptophan , biology , metabolism , biochemistry , amino acid
A series of recent studies have demonstrated that the immunoregulatory pathway of tryptophan catabolism, initiated by the enzyme indoleamine 2,3‐dioxygenase ( IDO ), is a critical participant in allergic inflammation. Originally known for its regulatory function during pregnancy and during chronic inflammation in tumorigenesis and infection, the activity of IDO seems to positively modify the inflammatory state of atopy or allergy. The tryptophan degradation pathway is important for tolerance induction during systemic allergen immunotherapy. Here, we focus on recent findings that establish the IDO pathway as central to allergic inflammation.