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Tryptase and histamine metabolites as diagnostic indicators of indolent systemic mastocytosis without skin lesions
Author(s) -
Doormaal J. J.,
Veer E.,
Voorst Vader P. C.,
Kluin P. M.,
Mulder A. B.,
Heide S.,
Arends S.,
KluinNelemans J. C.,
Oude Elberink J. N. G.,
Monchy J. G. R.
Publication year - 2012
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2012.02809.x
Subject(s) - tryptase , systemic mastocytosis , medicine , anaphylaxis , histamine , gastroenterology , urticaria pigmentosa , cutaneous mastocytosis , bone marrow , allergy , immunology , mast cell
Background Risk indicators of indolent systemic mastocytosis ( ISM ) in adults with clinical suspicion of ISM without accompanying skin lesions [urticaria pigmentosa ( UP )] are lacking. This study aimed at creating a decision tree using clinical characteristics, serum tryptase, and the urinary histamine metabolites methylimidazole acetic acid ( MIMA ) and methylhistamine ( MH ) to select patients for bone marrow investigations to diagnose ISM . Methods Retrospective data analysis of all adults, in whom bone marrow investigations were performed to diagnose ISM , was carried out. Results In total, 142 patients were included. SM was absent in all 44 patients with tryptase <10 μg/l, in 45 of 98 (46%) patients with tryptase ≥10 μg/l and in 18 of 52 patients (35%) with tryptase >20 μg/l. Above 43 μg/l, all patients had ISM ( n = 11). Male gender, insect venom anaphylaxis as presenting symptom, tryptase, MIMA , and MH were independent ISM predictors. If tryptase was ≥10 μg/l, the diagnostic accuracy of MIMA and MH was high (areas under the ROC curve 0.92). Conclusions In suspected patients without UP , the ISM risk is very low (if present at all) if tryptase is <10 μg/l. If tryptase is ≥10 μg/l, this risk depends on MIMA and MH , being low if these are normal, but high if these are elevated. Male gender and insect venom anaphylaxis are additional risk indicators. We recommend refraining from bone marrow examinations in suspected patients without UP if tryptase is <10 μg/l. Our results question the reliability of the minor diagnostic W orld H ealth O rganization criterion of tryptase >20 μg/l.