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The role of vitamin D in the immunopathogenesis of allergic skin diseases
Author(s) -
Benson A. A.,
Toh J. A.,
Ver N.,
Jariwala S. P.
Publication year - 2012
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2011.02755.x
Subject(s) - atopic dermatitis , vitamin d and neurology , medicine , allergy , immunology , asthma , food allergy
To cite this article: Benson AA, Toh JA, Vernon N, Jariwala SP. The role of vitamin D in the immunopathogenesis of allergic skin diseases. Allergy 2012; 67 : 296–301.AbstractVitamin D plays key roles in innate and adaptive immunity through the stimulation of Toll‐like receptors, increasing pro‐inflammatory cytokine production, and possibly enhancing T helper type 2 responses. These mechanisms may explain the growing body of evidence connecting vitamin D to allergic diseases, including asthma, food allergies, and allergic rhinitis. The data relating vitamin D to allergic skin diseases are equivocal with studies linking both high and low vitamin D levels to an increased risk of developing atopic dermatitis. In this paper, we describe the role of vitamin D in the immunopathogenesis of atopic dermatitis and other allergic skin diseases.