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Hematopoietic progenitor cells are innate Th2 cytokine‐producing cells
Author(s) -
Allakhverdi Z.,
Delespesse G.
Publication year - 2012
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2011.02703.x
Subject(s) - haematopoiesis , progenitor cell , immunology , chemokine , bone marrow , cytokine , stem cell , biology , microbiology and biotechnology , innate lymphoid cell , innate immune system , inflammation , immune system
To cite this article : Allakhverdi Z, Delespesse G. Hematopoietic progenitor cells are innate Th2 cytokine‐producing cells. Allergy 2012; 67 : 4–9. Abstract Typically, hematopoietic stem/progenitor cells (HSPCs) reside within the bone marrow (BM) where they give rise to all hematopoietic populations. However, HSPCs also constantly egress from the BM into the blood and circulate through the peripheral tissues where upon encounter with inflammatory stimuli and epithelial cell‐derived cytokines they rapidly release very high levels of Th2 cytokines/chemokines and differentiate into Th2 effector cells. The novel concept of the dual function of HSPCs as hematopoietic precursors and potent Th2 cytokine producers has important clinical implications in various inflammatory conditions, including allergic diseases.