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The in vitro diagnosis of drug allergy: status and perspectives
Author(s) -
Ebo D. G.,
Leysen J.,
Mayorga C.,
Rozieres A.,
Knol E. F.,
Terreehorst I.
Publication year - 2011
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2011.02661.x
Subject(s) - allergy , drug allergy , drug , medicine , immunoglobulin e , immunology , adverse drug reaction , in vitro , drug reaction , in vitro toxicology , adverse effect , pharmacology , biology , antibody , biochemistry
To cite this article: Ebo DG, Leysen J, Mayorga C, Rozieres A, Knol EF, Terreehorst I. The in vitro diagnosis of drug allergy: status and perspectives. Allergy 2011; 66 : 1275–1286. Abstract Adverse drug reactions (ADR) can result from immune‐mediated (drug allergy) and nonimmune‐mediated mechanisms. In both types of reaction, conclusive diagnosis and appropriate management remain major problems in daily clinical practice. This review summarizes the potentials and shortcomings of the currently available in vitro tests in the diagnosis of immediate (mostly IgE mediated) and nonimmediate (mostly T‐cell mediated) drug allergy, particularly quantification of specific IgE, flow‐assisted analysis of in vitro activated lymphocytes and basophils and the enzyme‐linked immunosorbent spot.