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IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8‐year‐olds
Author(s) -
Asarnoj A.,
Movérare R.,
Östblom E.,
Poorafshar M.,
Lilja G.,
Hedlin G.,
Van Hage M.,
Ahlstedt S.,
Wickman M.
Publication year - 2010
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2010.02334.x
Subject(s) - allergen , immunoglobulin e , sensitization , peanut allergy , immunology , medicine , allergy , pollen , cross reactivity , biology , antibody , botany , cross reactions
To cite this article: Asarnoj A, Movérare R, Östblom E, Poorafshar M, Lilja G, Hedlin G, van Hage M, Ahlstedt S, Wickman M. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization in 8‐year‐olds. Allergy 2010; 65 : 1189–1195. Abstract Background: Allergen‐specific IgE testing is often performed with crude peanut extract, but the results may be difficult to interpret because of cross‐reactions between peanut and other plant allergens. The aim was to investigate IgE reactivity to peanut allergen components in children from a birch‐rich region in relation to pollen sensitization and peanut symptoms. Methods: From a birth cohort, clinical parameters were obtained through questionnaires and IgE antibody levels to peanut and birch pollen were measured. Different peanut/birch sensitization phenotypes were defined among 200 selected children. IgE reactivity to peanut and pollen allergen components was analysed using microarray technique. Results: Peanut symptoms were reported in 87% of the children with IgE reactivity to any of the peanut allergens Ara h 1, 2 or 3 but not to Ara h 8 ( n = 46) vs 17% of children with IgE reactivity to Ara h 8 but not to Ara h 1, 2 or 3 ( n = 23), P < 0.001. Furthermore, symptoms were more severe in children with Ara h 1, 2 or 3 reactivity. Children with IgE reactivity both to Ara h 2 and to Ara h 1 or 3 more often reported peanut symptoms than children with IgE only to Ara h 2 (97% vs 70%, P = 0.016), particularly respiratory symptoms (50% vs 9%, P = 0.002). Conclusions: IgE analysis to peanut allergen components may be used to distinguish between peanut‐sensitized individuals at risk of severe symptoms and those likely to have milder or no symptoms to peanut if sensitized to pollen allergens and their peanut homologue allergens.