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Genetic variation in CRTh2 influences development of allergic phenotypes
Author(s) -
Cameron L.,
Depner M.,
Kormann M.,
Klopp N.,
Illig T.,
Von Mutius E.,
Kabesch M.
Publication year - 2009
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2009.02053.x
Subject(s) - single nucleotide polymorphism , haplotype , immunology , allergy , immunoglobulin e , snp , genetic variation , population , phenotype , asthma , medicine , genetic predisposition , genetic variability , biology , genotype , genetics , gene , antibody , environmental health
Background: Allergic disorders are characterized by an increase in the Th2 cytokines IL‐4, IL‐5 and IL‐13, produced primarily by Th2 cells. These cells are marked by the expression of CRTh2 ( c hemoattractant r eceptor‐homologous molecule expressed on Th2 cells), a receptor for prostaglandin D 2 . As genetic variation plays a significant role in the predisposition for allergic disorders, we investigated the influence of single nucleotide polymorphisms (SNPs) in CRTh2. Methods: In a large study population of German children ( n = 4264) from the International Study of Asthma and Allergy in Children (ISAAC II), six polymorphisms in CRTh2 were genotyped. Statistical analyses were performed using single SNP and haplotype analyses. Results: Uncorrected associations among −6373G>A, +1431G>C and +1538A>G were observed with a number of allergic phenotypes ( P < 0.05). After correction, association between +1431C and specific IgE to food allergens remained significant ( P = 0.04). Associations of haplotype (H)3 (containing +1538G) with reduced risk for asthma and H2 (containing +1431C) with increased risk for specific IgE to food allergens also remained significant after correction for multiple testing ( P = 0.004). Conclusions: Genetic variation within CRTh2 modifies the development of allergic sensitization and asthma in a population of German children.