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Interleukin‐12 family members and type I interferons in Th17‐mediated inflammatory disorders
Author(s) -
Goriely S.,
Cavoy R.,
Goldman M.
Publication year - 2009
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2009.02039.x
Subject(s) - immunology , interleukin 17 , t helper cell , medicine , pathogenesis , interleukin , t cell , inflammation , cytokine , immune system
Cytokines produced by antigen‐presenting cells govern the fate of helper T‐cell responses. Herein, we review the impact of interleukin (IL)‐23 and IL‐27 on the outcome of T‐helper (Th) 17 cell responses and discuss their impact in the pathogenesis of T‐cell‐mediated inflammatory disorders of autoimmune or allergic origin. We then discuss how type I interferons might influence the course of autoimmune diseases by tipping the balance between IL‐12 family members.