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Serum interleukin‐17 levels are related to clinical severity in allergic rhinitis
Author(s) -
Ciprandi G.,
De Amici M.,
Murdaca G.,
Fenoglio D.,
Ricciardolo F.,
Marseglia G.,
Tosca M.
Publication year - 2009
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2009.02010.x
Subject(s) - medicine , allergy , immunology , eosinophil , immunoglobulin e , interleukin 5 , interleukin , asthma , cytokine , antibody
Background: T helper (Th)‐17 cells are a subset of T helper lymphocytes that exert regulatory activities. Recently, it has been reported that serum interleukin (IL)‐17 levels are high in the most severe cases of birch allergy studied outside the pollen season. Objective: The aim of this study was to investigate a possible relationship between serum IL‐17 levels and clinical parameters in patients with allergic rhinitis studied during the pollen season. Methods: In all, 56 patients with persistent pollen‐induced allergic rhinitis were evaluated during the pollen season. Serum IL‐17 levels were evaluated by enzyme‐linked immunosorbent assay. Symptoms were assessed by visual analogue scale, drug use was monitored and peripheral eosinophils were counted. Results: Serum IL‐17 levels were significantly related to clinical symptoms, drug use and peripheral eosinophil counts ( P = 0.0001 for all). Conclusion: This study provides evidence that serum IL‐17 level assessment might be considered to classify allergy severity.