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The polymorphisms of Eotaxin 1 and CCR3 genes influence on serum IgE, Eotaxin levels and mild asthmatic children in Taiwan
Author(s) -
Wang T.N.,
Chiang W.,
Tseng H.I.,
Chu Y.T.,
Chen W.Y.,
Shih N.H.,
Ko Y.C.
Publication year - 2007
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2007.01485.x
Subject(s) - eotaxin , ccr3 , asthma , immunology , genotype , immunoglobulin e , medicine , pathogenesis , gene polymorphism , allergy , eosinophil , chemokine , gene , biology , inflammation , antibody , genetics , chemokine receptor
Background: Asthma is a complex disorder, which is known to be affected by interactions between genetic and environmental factors. The human Eotaxin 1 and CCR3 attract eosinophils and Th2‐lymphocytes to migrate to the inflammatory foci that could represent a key mechanism in allergy and asthma. Objective: We hypothesized that Eotaxin1 gene Ala23Thr and A‐384 G, and CCR3 gene T51C polymorphisms are associated with plasma Eotaxin levels and predispose individuals to asthma pathogenesis. Methods: One hundred seventy‐eight hospital‐based asthmatic children and 277 community‐based controls aged from 5 to 12 years were recruited in southern Taiwan. Whole blood samples and questionnaires were collected. In this study, we addressed genetic effects of Eotaxin 1 and CCR3 genes on asthma, plasma IgE and Eotaxin 1 levels. Results: In comparison with subjects with Ala23Ala genotype, Ala23Thr polymorphism of the Eotaxin 1 gene showed a significant protective effect on asthma (AOR = 0.58, 95% CI = 0.37–0.92). We demonstrated that the mean Eotaxin 1 concentration was significantly higher in subjects with Ala23Ala than in subjects with Thr23Thr ( P = 0.005) or Ala23Thr ( P = 0.07), which showed a gene‐dose dependent relationship. But, we observed that the A‐384G polymorphism of Eotaxin 1 gene and T51C polymorphism of CCR3 gene are not associated with asthma. Conclusion: This study finding provide a strong evidence that Eotaxin 1 Thr23Thr homozygote has a protective effect on asthma and significantly decreases plasma Eotaxin 1 concentrations in asthmatics in Taiwan.