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Two cases of occupational rhinitis caused by biodiastase in hospital and pharmaceutical workers
Author(s) -
Hur G.Y.,
Shin S.Y.,
Ye Y.M.,
Nahm D.H.,
Park H.S.
Publication year - 2007
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2007.01459.x
Subject(s) - library science , medicine , citation , family medicine , computer science
polymorphism were in Hardy–Weinberg equilibrium in both groups and did not differ between patients and controls (P = 0.95, v test) (Table 1). Total serum IgE levels were log-transformed before the comparisons. In allergic patients, one-way anova contrast of IgE levels using )109T>C genotypes (TT, TC and CC) was significant (P = 0.045) (Table 1). Difference in IgE levels between variant homozygotes and heterozygotes or wild-type genotypes ()109CC vs )109TC/TT) was not significant (P = 0.57), whereas under dominant model subjects carrying the variant allele had lower IgE than those with wild type genotype ()109TC/CC vs )109TT) (P = 0.01) (unpaired Student s t test). These results directly replicated findings by Hizawa et al. (6). Thus, similarly to the previous report, we used FCER1B )109TT homozygotes (high IgE genotype) as a reference for further analyses. FCER1A genotypes were grouped as previously described (1, 3). A further stratification of FCER1B )109TT (high IgE) and )109TC/CC (low IgE) genotypes on FCER1A compound genotypes (diplotypes) )344TT|)18483CC (high IgE) and )344CT/CC|)18483AC/AA (low IgE) resulted in significant differences (P = 0.005; one-way anova) (Table 1). Post hoc tests were significant for the contrast of allergic subjects with FCER1B )109TT & FCER1A )344TT|)18483CC (the highest IgE) vs FCER1B )109TC/CC & FCER1A )344CT/CC|)18483AC/AA genotype group (the lowest IgE) (P = 0.02; Bonferroni test) (Table 1). However, factorial anova contrasting FCER1B )109TT and )109TC/CC genotypes with FCER1A )344TT|)18483CC and )344CT/ CC|)18483AC/AA diplotypes revealed no multiplicative genetic interaction (P = 0.98). Thus, our results show that FCER1A )344C>T|)18483A>C and FCER1B )109T>C polymorphisms are related to total serum IgE levels in allergic patients in additive, rather than multiplicative, manner. Similar statistical inferences based on the control group data gave no significant results. However, FCER1B )109TT controls tended to have higher serum IgE levels than subjects carrying the variant )109C allele (P = 0.08; unpaired Student s t test). The interaction between FCER1A and FCER1B genes mutations was not studied before. To our knowledge, this is also the first report associating total serum IgE levels with FCER1B )109T>C polymorphism in Caucasians.