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Prolonged preseasonal treatment phase with Grazax sublingual immunotherapy increases clinical efficacy
Author(s) -
Calderon M. A.,
Birk A. O.,
Andersen J. S.,
Durham S. R.
Publication year - 2007
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2007.01416.x
Subject(s) - placebo , medicine , clinical trial , pollen , sublingual administration , anesthesia , biology , botany , alternative medicine , pathology
Background: Sublingual immunotherapy treatment with grass allergen tablets (Grazax ® ) is initiated preseasonally without up‐dosing and treatment is continued throughout the entire grass pollen season. Aims of the study: The influence of the duration of preseasonal treatment on clinical efficacy obtained within the grass pollen season was investigated. Methods: Data from three randomized, double‐blind, placebo‐controlled, multi‐centre trials with varying preseasonal treatment periods were analysed. In the grass pollen season, symptom and medication score reductions relative to placebo were calculated and correlated with the duration of the preseasonal treatment period. Results: The analysis was based on data from 934 patients. A significant reduction in seasonal daily rhinoconjunctivitis symptom and medication scores (17%, CI: 1–33% and 23%, CI: 1–47%, P < 0.05) was observed for patients treated with Grazax ® compared with placebo after approximately 8 weeks of pretreatment. The magnitude of the reductions in rhinoconjunctivitis symptom and medication scores increased with longer duration of preseasonal treatment ( P < 0.0001). Conclusions: Sublingual immunotherapy with Grazax ® must be initiated at least 8 weeks prior to the grass pollen season to provide a significant clinical efficacy. A longer preseasonal treatment period (>8 weeks) improves the clinical efficacy (relative to placebo) during the grass pollen season.