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EAACI/GA2LEN guideline: aspirin provocation tests for diagnosis of aspirin hypersensitivity
Author(s) -
NiżankowskaMogilnicka E.,
Bochenek G.,
Mastalerz L.,
Świerczyńska M.,
Picado C.,
Scadding G.,
Kowalski M. L.,
Setkowicz M.,
Ring J.,
Brockow K.,
Bachert C.,
Wöhrl S.,
Dahlén B.,
Szczeklik A.
Publication year - 2007
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2007.01409.x
Subject(s) - provocation test , aspirin , medicine , guideline , allergy , dermatology , immunology , pathology , alternative medicine
Aspirin and other nonsteroidal anti‐inflammatory drugs (NSAIDs) are among the most common causes of adverse drug reactions. Majority of them are of the hypersensitivity type. The two frequent clinical presentations of aspirin hypersensitivity are: aspirin‐induced bronchial asthma/rhinosinusitis (AIA/R) and aspirin‐induced urticaria/angioedema (AIU). The decisive diagnosis is based on provocation tests with aspirin, as the in vitro test does not hold diagnostic value as yet. Detailed protocols of oral, bronchial and nasal aspirin provocation tests are presented. Indications, contraindications for the tests, the rules of drug withdrawal and equipment are reviewed. Patient supervision and interpretations of the tests are proposed.