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The association of hepatitis A and Helicobacter pylori with sensitization to common allergens, asthma and hay fever in a population of young British adults
Author(s) -
Jarvis D.,
Luczynska C.,
Chinn S.,
Burney P.
Publication year - 2004
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.2004.00539.x
Subject(s) - hay fever , sensitization , medicine , immunology , asthma , helicobacter pylori , wheeze , population , immunoglobulin e , allergy , serology , antibody , environmental health
Background: A negative association of oro‐faecally spread infection with serological markers of sensitization and allergic disease has been reported. Method: Previous infection with hepatitis A and Helicobacter pylori was assessed in a community‐based sample of young British adults and associations with serum‐specific IgE to environmental allergens, asthma‐like symptoms and hay fever were examined. Results: There was no association of previous infection with hepatitis A or H. pylori with wheeze or hay fever. There was no evidence of an association of infection with either agent and sensitization except for the isolated finding of a lower prevalence of sensitization to grass in those with IgG antibodies to H. pylori (OR 0.65, 95% CI 0.43–0.99). This association did not explain the negative association of family size with sensitization to grass. Conclusion: In this population, there was no evidence that infection with hepatitis A or H. pylori was associated with lower levels of IgE sensitization, asthma or hay fever except for an isolated finding of a negative association of H. pylori infection with sensitization to grass.