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Allergic inflammation: cellular aspects
Author(s) -
Durham S. R.
Publication year - 1999
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1999.tb04429.x
Subject(s) - immunoglobulin e , immunology , allergic inflammation , immune system , antigen presentation , antigen presenting cell , inflammation , t cell , interleukin 4 , immunotherapy , eosinophilia , biology , medicine , antibody
Summary Tissue eosinophilia and IgE production during allergic inflammation are under the regulation of Th2‐type T cells. In addition, mast cells, basophils, and possibly eosinophils represent alternative sources of these cytokines, particularly UL‐4, which augments Th2 T‐cell development and local IgE production by B cells. Corticosteroids act by downregulating Th2 responses, whereas immunotherapy acts either by inhibiting immune deviation in favour of Th1 responses with augmentation of IgG production by B cells, Tho/Thou by inducing T‐cell anergy with downregulation of Tho/Th2 responses. The role of the antigen‐presenting cell is pivotal in determining T‐cell differentiation. Th2 development is favoured by low‐antigen‐concentration presentation by B cells and/or dendritic cells, in the presence of IL‐4. Novel strategies directed against IL‐4, IL‐5, and IgE are currently under investigation.