Premium
Sensitization to triglycidylisocyanurate (TGIC) with cutaneous and respiratory manifestations
Author(s) -
Meuleman L,
Goossens A,
Rochette F,
Nemery B,
Linders C
Publication year - 1999
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1999.00103.x
Subject(s) - medicine , asthma , dermatology , provocation test , sensitization , contact dermatitis , allergen , patch testing , inhalation , allergy , immunology , pathology , anesthesia , alternative medicine
The case is presented of a man with allergic contact dermatitis and occupational asthma due to triglycidylisocyanurate (TGIC), which is used as a hardener in thermosetting powder paint. The contact dermatitis was confirmed by patch testing (TGIC 0.5% and 5% in petrolatum), and the occupational asthma was confirmed by bronchial provocation testing: two challenges to an aerosol of lactose containing TGIC (0.05% and 0.1%, w/w, each for 0.5+1+2+4 min) led to a maximal decrease in FEV 1 of 22% and 31% after 6 and 4 h, respectively. Skin prick tests with unconjugated TGIC were possibly positive. This case confirms that exposure to TGIC in powder paints may cause not only contact dermatitis, but also occupational asthma.