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B‐ and T‐cell epitopes of tropomyosin, the major shrimp allergen
Author(s) -
Rao P. V. Subba,
Rajagopal D.,
Ganesh K. A.
Publication year - 1998
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1998.tb04959.x
Subject(s) - tropomyosin , epitope , shrimp , allergen , peptide , peptide sequence , immunoglobulin e , amino acid , biology , allergy , immunology , microbiology and biotechnology , chemistry , antibody , biochemistry , gene , actin , fishery
The major crustacean allergen characterized from different species of shrimp is the muscle protein tropomyosin. Two shared epitopes corresponding to 47-63 and 150-158 of the deduced amino-acid sequence of the brown shrimp, M. ensis, were identified as IgE-binding B-cell epitopes. A 21-mer peptide spanning the amino-acid residues 261-281 was identified as a putative T-cell epitope capable of reducing ongoing tropomyosin-specific IgG and IgE responses in a mouse model. These observations suggest that peptide immunotherapy may also be effective in the treatment of food hypersensitivity.