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Olive‐pollen profilin. Molecular and immunologic properties
Author(s) -
Ledesma A.,
Rodríguez R.,
Villalba M.
Publication year - 1998
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1998.tb04090.x
Subject(s) - profilin , pollen , immunopathology , allergen , immunology , allergy , medicine , chemistry , biology , botany , biochemistry , actin cytoskeleton , cytoskeleton , cell
Olive‐pollen profilin has been isolated and characterized as a significant allergen. Its molecular properties, such as a molecular mass of 15 kDa; amino‐acid composition; and secondary repetitive structure percentages of 15%α‐helix, 33%β‐strand, 20%β‐turn, and 32% random coil, have been determined. Its allergenic capability, a recognition frequency estimated at 24% of olive‐hypersensitive patients, and high cross‐reactivity with all the pollen used have been found. The presence of conformational epitopes in the olive profilin, as well as a high structural and immunologic similarity to other pollen sources such as birch and ash, can be established from these studies.