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Blood eosinophils and serum IgE as predictors for prognosis of interferongamma therapy in atopic dermatitis
Author(s) -
Noh G.W.,
Lee K.Y.
Publication year - 1998
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1998.tb03842.x
Subject(s) - atopic dermatitis , medicine , eosinophil , immunoglobulin e , immunology , allergy , gastroenterology , asthma , antibody
Background Interferon‐gamma (IFN‐γ) therapy has been reported to be effective in atopic dermatitis. However, IFN‐γ therapy in atopic dermatitis has not yet been well established, ln this study, immunologic variables were evaluated as predictors for the prognosis of IFN‐γ therapy in atopic dermatitis Methods Sixty‐eight atopic dermatitis patients were each treated 18 times with 2 X 10 6 units/m 2 IFN‐γ. Blood IgE level, eosinophil percentage, eosinophil count, and levels of IFN‐γ, interIeukin‐4 (IL‐4), IL‐5, and IL‐10 were investigated. According to clinical responses, patients were classified into three groups: patients with improved clinical severity scores of over 20% were included in group A; those with improved scores of 20% or less in group B; and those with no improvement in group C. Results Serum IgE levels and blood eosinophil percentages were the lowest n group A. Most atopic dermatitis patients with an eosinophil percentage over 9% and IgE level over 1500 lU/ml did not respond to IFN‐γ therapy. Initial IL‐10 levels were the highest in group A. IL‐4 levels in group A, and IL‐5 and IL‐10 levels in all groups were significantly decreased by IFN‐γ therapy. Conciusions WN‐y therapy may be recommended for atopic dermatitis patients with blood eosinophil percentages less than 9% and serum IgE levels less than 1500 lU/ml.