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Milestones in the biology and pharmacology of histamine H 1 ‐receptor antagonists
Author(s) -
Marone Gianni
Publication year - 1997
Publication title -
allergy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.363
H-Index - 173
eISSN - 1398-9995
pISSN - 0105-4538
DOI - 10.1111/j.1398-9995.1997.tb04806.x
Subject(s) - histamine , pharmacology , in vivo , allergy , antagonism , effector , histamine receptor , histamine h4 receptor , mediator , anaphylaxis , immunology , histamine h1 receptor , in vitro , receptor , inflammation , histamine h1 antagonists , allergic inflammation , mast cell , medicine , histamine h2 receptor , biology , antagonist , biochemistry , microbiology and biotechnology
Daniele Bovet's pioneering discovery that a series of compounds possessing anti‐histamine activity reduced the symptoms of anaphylaxis provided the proof that histamine plays a pivotal role as a mediator of allergic reactions. Basophils and mast cells are the major sources of histamine in man and they are thus one of the primary effector cells of allergic inflammation. Some H 1 ‐receptor antagonists posseses a variety of antiinflammatory activity to H 1 ‐ ‐ antagonism in vitro and in vivo . This promising area should be explored further and much remains to be done in the evaluation of the immunodulatory effects of anti‐histamines.